As far as I am concerned the "indian wars" were before the time of WQ3
which plays around the turn of the 19th century (Tso you might confirm this), so you cannot act in that historical background.
The "indians issue" was often discussed by Spoon and me orally.
We really don't want to judge history in this game.
We thought about placing the indians ingame just like any outlaw or lawman.
We don't want to do sort of "indians vs. white settlers" gamemode refering to historical events, there will be one indian character for each team (so there are indians in both teams, good and bad).
Maybe they will have special weapons e.g. tomahawk instead of the knife...
but because of the game balance they should also have access to the standard arsenal.
I can't imagine that there will be lawman/outlaw players killing indian players (or the other way around) because of the historical background.